Allele-Specific KRT1 Expression Is a Complex Trait

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Allele-Specific KRT1 Expression Is a Complex Trait

The differential expression of alleles occurs commonly in humans and is likely an important genetic factor underlying heritable differences in phenotypic traits. Understanding the molecular basis of allelic expression differences is thus an important challenge. Although many genes have been shown to display differential allelic expression, this is the first study to examine in detail the cumula...

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Genetic variation in populations can result in variation in levels of gene expression but the extent to which this occurs has been unclear. In this article, recent studies of allele-specific expression among autosomal non-imprinted genes are reviewed. These new data provide evidence that differential expression is relatively common and that allelic differences are heritable and can be highly co...

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ژورنال

عنوان ژورنال: PLoS Genetics

سال: 2006

ISSN: 1553-7404

DOI: 10.1371/journal.pgen.0020093